Monday, 23 July 2018

abcam Cancer and Metabolism Conference 2018- 1/3

I recently attended abcam’s Cancer and Metabolism conference in Cambridge and realise that I haven’t written about it yet. 


In a nutshell, the event covered major aspects of metabolic transformation in cancer and attempted to highlight potential therapeutic approaches to target cancer-specific metabolic pathways. The conference allowed me to build on my existing knowledge of metabolism and metabolic signalling in cancer and introduced me to more advanced concepts, novel methods, and emerging technologies to target these pathways.

I was also introduced to a collaborative European wide research project called TRANSMIT: Translating the role of Mitochondria in Tumorigenesis. 

The angle they are taking with TRANSMIT is viewing cancer as not only a genetic, but also a metabolic disease. 

TRANSMIT Project- https://www.transmit-project.eu

Personally I think it is a metabolic disease with metabolic solutions and the genetic mutations are as a result of mitochondrial dysfunction. With healthy mitochondria it is my belief that you simply do not get cancer. However… whether it is cause or effect, the focus on cancer metabolism is a huge step in the right direction for me and I am greatly encouraged by seeing this type of event take place and to be able to have these conversations. 

The research I came across at this conference was all work that could directly be translated to the patient (‘from bench to bedside’) so I found this more engaging than most conferences I have been to. 

More and more now scientists are not only investigating the conribution of oncogenes and tumour suppressor genes (an approach which, as the primary focus over the years has been woefully ineffective), but we are also focusing on the intricate metabolic plasticity that transformed cells undergo to survive the adverse, volatile tumour microenvironment conditions. 

The mitochondria is the star player here, and rightly so, because they act as key players in cancer metabolic restructuring due to their crucial role in powering all functions of the cell by producing complex molecules for function, growth and survival. When these normal processes become aberrant, causing dysfunction, as is the case with cancer, this biosynthetic powerhouse of the cell is forced to adapt through more anaerobic respiration, and so is forced to provide energy and metabolites to the cell in different ways. 

These cells are very clever and can learn how to survive by using different substrates to stay alive and will become more resiliant with time if provided with the fuel that it needs to thrive. It will then become more able to use alternative substrates for energy as it adapts and learns, and here we have parallels with Darwinian biology. In the absence of nutrients, cancer cells can even scavenge from cellular debris in a process called ‘macropinocytosis’, so this is worth considering with any metabolic therapy, most likely it seems when necrotic tissue is a hallmark of disease as it often is with glioblastoma. That’s my opinion anyway, seems to make sense. Cancer doesn’t want to die, as a result of these metabolic abnormalities we have an occurance of mutations in metabolic enzymes encoded by both nuclear and mitochondrial DNA. 

It is my belief therefore, that more solid tumours would be most responsive to any kind of metabolic approach, as they have clear margins, are less diffuse and invasive, and as such have likely not yet progressed to being able to use multiple substrates to become more resilient to targeted metabolic therapies. More aggressive malignancies will likely require a combination approach of dietary manipulation and drugs targetting key metabolic targets in line with what the tumour’s metabolic signature may dictate. 

Electron microscopy morphology of the mitochondrial network
in gliomas and their vascular microenvironment-
https://www.sciencedirect.com/science/article/pii/S0005272810007437


As I began listening to the talks, the main research challenges became eminently clear. 

Firstly, we need to continue to learn about the bioenergetic plasticity of cancer in general. We have established that mitochondrial function and respiration play fundamental roles in the development and progression of cancer. The main challenges here are noted below numerically and although of major importance as a primary substrate for most cancers, its not all about the glucose:

1. Many malignancies have been shown to be able to utilise not only glucose, but also glutamine for generating cellular energy and provide metabolic building blocks to proliferate.

2. As stated, many cancers generate most of their cellular energy via mitochondrial respiration and oxidative phosphorylation (OxPhos). Glutamine is the preferred substrate for OxPhos in tumour cells.

3. Cancer cells are remarkably adaptable at using different substrates for fuel. They can even use metabolic substrates donated by ‘stromal cells’ for cellular energy generation via OxPhos. Stromal cells are present in the tumour microenvironment and are not necessarily malignant themselves but can provide the tumour with substrates it needs to keep growing.

4. Bioenergetic plasticity of cancer is a major consideration if we want to attempt to predict, understand and monitor a metabolic approach to treating cancer more effectively.

See below a poster displaying an outline of the work various research groups are undertaking as part of the TRANSMIT project:



How might we achieve this:

1. By targeting metabolic enzymes and coenzymes

2. Learning more about metabolic features of cancer cells in general. This can help us with therapeutic efficacy testing and biomarker discovery. 


Primary aims that I could see from this research:

1. Help to overcome chemoresistance

2. Come up with metabolic intervention strategies. 

3. Better understand the role of the mitochondria in cancer initiation and progression. 

4. Understanding of metabolic signatures of tumours that may respond to the ketogenic diet or specific nutrient deprivation diets. 


Dietary and drug strategies covered:

1. An energy restricted ketogenic diet. (high fat, low carb, adequate protein)

Most cancer cells thrive on glucose as major energy source and partly posess dysfunctional mitochondria leading to a reduced ability to metabolise fat. This approach is being studied as an adjunct to the standard of care. It may reduce tumour growth and prolong survival. 

2. Amino acid deprivation diets.

- Glutamine (protein restriction, temporary inhibition of enzymes involed likely more suitable)
- Methionine, cysteine

3. Fasting and diets that mimic a fasted state.

4. Drugs and drug targets

- Glutaminase inhibitors as a major target for the majority of cancers. For brain cancer perhaps more important in neuroblastoma (considered a real glutamine hog) and tumours that use up glutamine as the primary or major fuel alongside glucose as major substrates.

- Tryptophan degrading enzymes (overcoming tumour immune resistance)

- Citrin blockers- citrin is upregulated in multiple cancers.

- Targeting other novel metabolic pathways (aspartate, folate, serine, sapienate)

- Dichloroacetate (DCA)- PDK inhibitor (Pyruvate dehydrogenase kinase)- mitochondrial enzyme activated in a variety of cancers. Pyrimidine biosynthesis and growth of SDH (Succinate dehydrogenase) deficient cells is also inhibited by this drug.

- Biguanides and Kinase Inhibitors (KI)- induce opposing effects on key metabolic pathways that fuel cancer (eg. inhibition of mTOR. MTOR regulates mRNA translation initiation). 


Areas of focus: TRANSMIT

1. Cancer bioenergetics of different tumours. 

I have MR Spectroscopy, for example, and we can identify different metabolic signatures pertaining to different types of brain tumour fairly accurately from this. There may be some problems looking at areas where there is brain damage however, showing false positive results as you may see high signalling activity. It can sometimes be difficult to differentiate between malignant activity and areas of brain damage. 

2. How metabolic factors influence how cancer cells adapt to survive and proliferate could identify mitochondrial metabolic biomarkers for characterising the transformation from benign to cancer cells. 


What TRANSMIT is working on more specifically:

-Metabolic reprogramming of cancer cells- ie coordination of glutaminolysis and glycolysis. 

- Work with cancer cell models, metabolic intervention strategies.

- Improve our understanding of cancer pathology. 

- Understanding the role of fumarate hydratase in tumorigenesis.

- The mitochondrial complex 1 driven regulation of the hypoxic response in cancer cells. 

- Identifying coenzymes in cancer cells. 

29 comments:

  1. My mum had small cell terminal lung cancer. She lost her hair while going through chemo and it was devastated. She has recently finished her radiotherapy and she was losing her hair again :( mum wanted me to shave it off again as it's coming out in clumps.i know she was very upset and have told her to be confident it'll grow back but she's so upset, life became hell for me, because i just cant imagine my mum this way. i actually posted this online, and somebody replied me, that he knows once who can cure my mum, without spending much money and without taking anytime anymore, and there wont be any hair loss anymore. I said okay and i want to give it a try, the person that helped him (the person that i was referred to) is Dr Covenant, his email is covenantsolutiontemple@gmail.com, he gave me his email address and i contacted him and told him everything, he (Dr Covenant) said i should not worry everything'll be okay in space of 8 days, i actually gave him a try.
    It was not up to the 3rd day, i started noticing changes in my mum. Now my mum is healthy back and the cancer is gone. Am so grateful about this. I actually thought that my mum was going to die, but now she is still alive. Friends, if you have any problem such as cancer, or other illness like HIV/AIDS, GONORRHEA, or any other illness at all, and he is also specialized in getting ex back contact Dr Covenant on his email covenantsolutiontemple@gmail.com or add him on watsapp on +2349057353987 or call him directly on +2348146671563. you can also go through his website if interested http://covenantspelltemple.blogspot.com.
    MY BEST FRIEND IS STILL ALIVE, AM GRATEFUL COVENANT.

    ReplyDelete
    Replies
    1. Hello viewer’s
      I don’t have much to say there are so may scammers going on online so we cant detect the real herbal medicine doctors. Thank GOD for leading me, please don’t ignore this post is real Dr Emmanuel, is a real herbal Doctor, he cured me from Brain tumor, i am living so happy and free , i was fully recovered within 4 weeks of usage of dr Emmanuel herbal medicine ,please viewers out there that have any deadly disease don't fail to contact him via his email; traditionalherbalhealingcentre@gmail.com or WhatsApp/Call: +2348140033827 thanks once again to dr Emmanuel GOD bless you abundantly

      Delete
    2. POWERFUL SPELL CASTER THAT BROUGHT MY EX HUSBAND BACK INTO MY LIFE AFTER HE LEFT ME EMAIL HIM VIA EMAIL INFINITYLOVESPELL@GMAIL.COM OR INFINITYLOVESPELL@YAHOO.COM ADD HIM ON WHATSAPP +2348118829899

      Hello my fellow friends online I'm Diana Gilbert from USA, I want to use this medium to thank Dr Great because he brought back my Ex husband. my husband left me for his ex girlfriend he had before he married me it's a difficult situation for me I called and beg him to come back he refused he said he don't love me anymore I tried every possible way to get him back all was in vain I told my friend about it and she gave me Dr Great email and I emailed him and told him my problem and he told me what to do and I did it and he cast a love spell which brought back my husband within 24 hours. If you need help in getting back together with your Ex, email Dr Great at infinitylovespell@gmail.com or infinitylovespell@yahoo.com WhatsApp him+2348118829899 visit my blog http://dianagilbert05.over-blog.com/






      POWERFUL SPELL CASTER THAT BROUGHT MY EX HUSBAND BACK INTO MY LIFE AFTER HE LEFT ME EMAIL HIM VIA EMAIL INFINITYLOVESPELL@GMAIL.COM OR INFINITYLOVESPELL@YAHOO.COM ADD HIM ON WHATSAPP +2348118829899

      Hello my fellow friends online I'm Diana Gilbert from USA, I want to use this medium to thank Dr Great because he brought back my Ex husband. my husband left me for his ex girlfriend he had before he married me it's a difficult situation for me I called and beg him to come back he refused he said he don't love me anymore I tried every possible way to get him back all was in vain I told my friend about it and she gave me Dr Great email and I emailed him and told him my problem and he told me what to do and I did it and he cast a love spell which brought back my husband within 24 hours. If you need help in getting back together with your Ex, email Dr Great at infinitylovespell@gmail.com or infinitylovespell@yahoo.com WhatsApp him+2348118829899 visit my blog http://dianagilbert05.over-blog.com/

      Delete
    3. what a greatest surprise to me that i was cured from Hiv/Aids virus by a powerful herbal doctor, it was just like a dream to me i taught that their is no cure for Hiv/Aids because for about six years i spent so much of my money in hospital but no improvement i was confuse in life until a friend of mine introduce me to this herbal doctor i contacted him on email: nativehealthclinic@gmail.com or WhatsApp/Call him at +2348140073965 if their can be any help and he promise to help me, he prepared a herbal medicine for me i followed his instruction after 18 days i went to hospital for test but i was cured it was a greatest surprise to me so i decide to share this testimony. a very big thanks to this herbal doctor who save my life, please if you have this kind of sickness or any disease do not give up you can contact him whatsapp him on +2348140073965..

      Delete
    4. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346



      i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346

      Delete
  2. I was hurt and heart broken when my husband left me with two kids for one year, All effort to bring him back failed I thought I'm not going to see him again not until I met a lady called Jesse who told me about a spell caster called Dr.Oku, She gave me his email address and mobile number and I contacted him and he assured me that within 28 hours my husband will come back to me, In no less than 28hours my husband came back started begging for forgiveness saying it is the devils work, so I'm still surprise till now about this miracle,i couldn't conceive but as soon as the spell was cast,i became pregnant and gave birth to my third child(Michelle) if you need any assistance from him you can contact him via:email; okutemple@gmail.com , you can also call him or add him on Whats-app: +2347053113465 and tell him I referred you to him

    ReplyDelete
  3. Il ruolo del Sodio Nel cancro
    Per affamare Le cellule Tumorali, non è necessario ridurre il consumo di proteine e glucidi. Per affamare il tumore, basta ridurre il consumo di sodio (NaCl), dalla dieta. Devi sapere che la glutammina ed il glucosio, entrano nella cellula tumorale, accoppiati al sodio; se i livelli di sodio sono bassi, il glucosio e gli aminoacidi non riescono ad essere assorbiti dalla cellula tumorale. Le cellule Tumorali sono avide di Glucosio, glutammina e Sodio; Se il sodio è poco, glucosio e glutammina rallentano l'assorbimento.
    La Dieta Gerson per esempio è una dieta povera di sodio e ricco di magnesio e potassio. Attenzione! un po di sodio nella dieta ci vuole....

    ReplyDelete
  4. Hello viewer’s
    I don’t have much to say there are so may scammers going on online so we cant detect the real herbal medicine doctors. Thank GOD for leading me, please don’t ignore this post is real Dr Emmanuel, is a real herbal Doctor, he cured me from Brain tumor, i am living so happy and free , i was fully recovered within 4 weeks of usage of dr Emmanuel herbal medicine ,please viewers out there that have any deadly disease don't fail to contact him via his email; traditionalherbalhealingcentre@gmail.com or WhatsApp/Call: +2348140033827 thanks once again to dr Emmanuel GOD bless you abundantly

    ReplyDelete
  5. Hello viewer’s
    I don’t have much to say there are so may scammers going on online so we cant detect the real herbal medicine doctors. Thank GOD for leading me, please don’t ignore this post is real Dr Emmanuel, is a real herbal Doctor, he cured me from Brain tumor, i am living so happy and free , i was fully recovered within 4 weeks of usage of dr Emmanuel herbal medicine ,please viewers out there that have any deadly disease don't fail to contact him via his email; traditionalherbalhealingcentre@gmail.com or WhatsApp/Call: +2348140033827 thanks once again to dr Emmanuel GOD bless you abundantly

    ReplyDelete
  6. Natural herbs can cure epilepsy, I had epilepsy for over 14 years, i have spent a lot money getting drugs from the hospital to keep me healthy, I went to many hospitals for cure but there was no solution, One day I was in the office going through the internet when I saw a post about Dr Itua herbal medicine on how he cure a Lady from Kansas who was suffering from HIV and she listed Epilepsy as list of illness Dr Itua can as well cured I contacted him with epilepsy Cure solution, I email him. He told me the things I need to do and also give me instructions to take, which I followed properly. Before I knew what is happening after two weeks To my greatest surprise after patiently going according to instruction given to me by Dr Itua, my epilepsy was cure, I want to say a big thanks to Dr Itua who God have sent to heal his people with his natural medicine I pray that God will bless you for the good work you are doing.for all who are still suffering from this illness, you can also contact him through his email on :;;drituaherbalcenter@gmail.com Or Whatsapp Number...+248149277976 like they say his herbal remedy is the only permanent solution to Seizure. He Can as well cure the following... Herpes Virus, HIV/Aids, Hepatitis A/B, Shingles, Cold Sore, Epilepsy, Wart, Lupus, Diabetes, Men/Woman Infertility, Seizure, Cancer all types.

    ReplyDelete
  7. I was diagnosed with stage 3 breast cancer in August of 2010. A precious friend told me about Dr Itua Herbal Center in West Africa,She gave me his contact number and email address,I contacted him quickly so he give me guaranty that his herbal medicine will cure my cancer and i will be heal forever I said Okay.I ask him about the process for the cure,he ask me to pay for the fees which i did and within 7 working days he sent me the herbal medicine then he instructed me on how to drink it for two weeks to cure.I told Gomez my friend about the herbal medicine so he gave me go ahead to drink it.So after drinking it for two weeks i was cured I'm so grateful and i promise i will recommend anyone with cancer to him and that what i'm doing.Dr Itua Herbal Medicine makes me believes there is a hope for people suffering from,Parkinson's disease,Schizophrenia,Cancer,Scoliosis,Bladder Cancer,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Skin Cancer,Uterine Cancer,Prostate Cancer,Fibromyalgia,a
    Syndrome Fibrodysplasia ,Epilepsy Dupuytren's disease, Diabetes ,Coeliac disease, Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Sclerosis,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic diseases.Hiv_ Aids,Herpes,Inflammatory bowel disease ,Copd,Diabetes.
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    ReplyDelete
  8. Dr Itua cure my HIV, I have been a ARV Consumption for 10 years. i have been in pains until i came across Dr Itua on blogs site.I emailed him about my details of my HIV and my location i explained every thing to him and he told me that there is nothing to be scared of that he will cured me, he gave me guarantee,He ask me to pay for items fees so when i'm cured I will show gratitude I did and giving testimony of his healing herbs is what I'm going to do for the rest of you out there having HIV and other disease can see the good work of Dr Itua.I received his herbal medicine through EMS Courier service who delivered to my post office within 5 working days.Dr Itua is an honest man and I appreciate him for his good work.My GrandMa called him to appreciate him and rest of my friends did too,Is a joy to me that I'm free of taking Pills and having that fat belle is a nightmare.you will understand what i'm talking about if you have same problem I was having then not now though.I'm free and healthy Big Thanks To Dr Itua Herbal Center.I have his calendar too that he recently sent me,He Cure all kind disease Like,Cancer,Herpes,Fibromyalgia,Hiv,Hepatitis B,Liver/Kidney Inflamatory,Epilepsy,Infertility,Fibroid,Diabetes,Dercum,Copd ,and also Bring back Ex Lover Back..Here his Contact .drituaherbalcenter@gmail.com Or Whats_app Number +2348149277967

    ReplyDelete
  9. POWERFUL SPELL CASTER THAT BROUGHT MY EX HUSBAND BACK INTO MY LIFE AFTER HE LEFT ME EMAIL HIM VIA EMAIL INFINITYLOVESPELL@GMAIL.COM OR INFINITYLOVESPELL@YAHOO.COM ADD HIM ON WHATSAPP +2348118829899

    Hello my fellow friends online I'm Diana Gilbert from USA, I want to use this medium to thank Dr Great because he brought back my Ex husband. my husband left me for his ex girlfriend he had before he married me it's a difficult situation for me I called and beg him to come back he refused he said he don't love me anymore I tried every possible way to get him back all was in vain I told my friend about it and she gave me Dr Great email and I emailed him and told him my problem and he told me what to do and I did it and he cast a love spell which brought back my husband within 24 hours. If you need help in getting back together with your Ex, email Dr Great at infinitylovespell@gmail.com or infinitylovespell@yahoo.com WhatsApp him+2348118829899 visit my blog http://dianagilbert05.over-blog.com/

    ReplyDelete
  10. POWERFUL SPELL CASTER THAT BROUGHT MY EX HUSBAND BACK INTO MY LIFE AFTER HE LEFT ME EMAIL HIM VIA EMAIL INFINITYLOVESPELL@GMAIL.COM OR INFINITYLOVESPELL@YAHOO.COM ADD HIM ON WHATSAPP +2348118829899

    Hello my fellow friends online I'm Diana Gilbert from USA, I want to use this medium to thank Dr Great because he brought back my Ex husband. my husband left me for his ex girlfriend he had before he married me it's a difficult situation for me I called and beg him to come back he refused he said he don't love me anymore I tried every possible way to get him back all was in vain I told my friend about it and she gave me Dr Great email and I emailed him and told him my problem and he told me what to do and I did it and he cast a love spell which brought back my husband within 24 hours. If you need help in getting back together with your Ex, email Dr Great at infinitylovespell@gmail.com or infinitylovespell@yahoo.com WhatsApp him+2348118829899 visit my blog http://dianagilbert05.over-blog.com/

    ReplyDelete
  11. what a greatest surprise to me that i was cured from Hiv/Aids virus by a powerful herbal doctor, it was just like a dream to me i taught that their is no cure for Hiv/Aids because for about six years i spent so much of my money in hospital but no improvement i was confuse in life until a friend of mine introduce me to this herbal doctor i contacted him on email: nativehealthclinic@gmail.com or WhatsApp/Call him at +2348140073965 if their can be any help and he promise to help me, he prepared a herbal medicine for me i followed his instruction after 18 days i went to hospital for test but i was cured it was a greatest surprise to me so i decide to share this testimony. a very big thanks to this herbal doctor who save my life, please if you have this kind of sickness or any disease do not give up you can contact him whatsapp him on +2348140073965..

    ReplyDelete
  12. Hiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patent we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patent Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal Center.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Drituaherbalcenter.Here his contact Number +2348149277967...He assure me he can cure the following disease..Hiv,Cancer,Herpes Virus,Hpv,Pile,Weak Erection,Lyme Disease,Epilepsy, ,Bladder Cancer,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Non Hodgkin Lymphoma,Skin Cancer,Lupus,Uterine Cancer,Prostate Cancer, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Stroke,Hpv,Weak Erection,Liver/Kidney Inflammatory,Men/Woman infertility, bowel disease ,Huntington's disease ,Diabetes,Fibroid.

    ReplyDelete
  13. Most prostate cancers are adenocarcinomas, cancers that arise in glandular cells of the prostate’s epithelial tissue. Prostate cancers usually progress slowly and produce no symptoms in the initial stages. Eventually, the tumor may enlarge like mine use too, the prostate gland, pressing on the urethra and causing painful or frequent urination and blood in the urine. So I was so uncomfortable with this prostate cancer diseases then I decided to do online search on how to cure cancer because I well have read a lot about herbal medicine,I came across a lot of testimony how Dr Itua cure HIV/herpes then Cancer was listed below the comment.with courage I contacted Dr Itua and he sent me his herbal medicine through Courier service then I was asked to pick it up at my post office which i quickly did. I contacted Dr Itua that i have received my herbal medicine so he instructs me on how to drink it for three weeks and that is how Dr Itua Herbal Medicine cure my prostate Cancer, The treatment takes three weeks and I was cured completely. Dr Itua is a god sent and I thank him every day of my life. Contact him now On:Email:drituaherbalcenter@gmail.com/Whatsapp:+2348149277967.
    He listed to that he can as well cure the following diseases below.... Cerebral Amides. Lung Cancer, Alzheimer's disease, Adrenocortical carcinoma. Alma, Uterine Cancer, Breast Cancer, Allergic diseases. Kidney cancer, Love Spell, Colo rectal cancer, Lottery Spell, Bladder Cancer, Skin Cancer, HIV /Aids, Herpes, Non-Hodgkin lymphoma, Inflammatory bowel disease, Copd, Diabetes, Hepatitis

    ReplyDelete
  14. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346



    i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346

    ReplyDelete

  15. So is possible that HIV Disease can be cured because I have been scammed so many times not until I came across this great man Dr Akhigbe who helped me at first I never believe all this comment and post about him and I was very sick because I have been infected with HIV/AIDS for the past two year,just last 2 months I keep reading the testimony about this man named Dr Akhigbe they said that the man is so powerful he have cured different type of diseases, I keep monitoring his post of some people about this man and I found out that he was real so I decided to give him a trial I contacted him for help and he said he was going to help me get my cure that all I needed to do was to send him money to prepare the medication after which it will be sent to me via DHL courier delivery services which I did to my greatest surprise the medication was sent to me he gave me instructions to follow on how to drink it that after three weeks I should go for check up,after taking the medicine and follow his instruction after three weeks I went back to the hospital for another test, at first I was shocked when the doctor told me that I was negative I ask the doctor to check again and the result was still the same negative that was how I free from HIV VIRUS at of the shock I decided to come and share my own testimony with you for those who think there is no cure for HIV VIRUS the cure as finally come' out stop doubting and contact Dr Akhigbe via email drrealakhigbe@gmail.com he will help you out you can also whatsApp him via +2348142454860 he is also perfect in curing DIABETICS,HERPES,HIV/AIDS, ;ALS, CANCER ,HEPATITIS A AND B,ASTHMA, HEART DISEASE, CHRONIC DISEASE.,KIDNEY DISEASE, LUPUS, EPILEPSY,STROKE, ECZEMA, EATING DISORDER etc believe me that deadly disease is not longer a deadly sentence because dr akhigbe has the cure.the godfather of herbal root.
    email: drrealakhigbe@gmail.com whatsapp number: +2348142454860
    website: https://drrealakhigbe.weebly.com

    ReplyDelete
  16. I saw so many testimonies about Dr Itua a great HERBAL DOCTOR that can cure all kind of diseases and give you the rightful health to live a joyful life, i didn't believe it at first, but as the pain got worse and my life was at risk after visiting my therapist numeriuos times for combination of treatments. and no changes so i decided to take a try, I contacted him also and told him i want a cure for Vulvar cancer/ Testicular cancer and it was Stage IIIA, he gave me advice on what i must do and he delivered it to me in my state which i use according to his instruction, and today i must say I am so grateful to this man Dr Itua for curing me from Vulvar cancer/ Testicular cancer and for restoring me back to my normal health and a sound life,i am making this known to every one out there who have been living with cancers all his life or any sick person should not waist more time just contact him with his details below- WhatsApp- +2348149277967 Email drituaherbalcenter@gmail.com, believe me this man is a good man with Godly heart, this is the real secret we all have been searching for. Do not waste more time contact him today for you also to live a sound and happy life. he cure the following disease________Thyroid Cancer,Uterine cancer,Fibroid,Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Scoliosis,Brain Tumor,Fibromyalgia, Fluoroquinolone Toxicity Bladder cancer,Brain cancer,Hiv,Herpes,Esophageal cancer,Gallbladder cancer,Gestational trophoblastic disease,Head and neck cancer,Hodgkin lymphoma
    Intestinal cancer,Kidney cancer,Hpv,Lung cancer,Melanoma,Mesothelioma,Multiple myeloma,Neuroendocrine tumors
    Non-Hodgkin lymphoma,Oral cancer,Ovarian cancer,Sinus cancer,Hepatitis A,B/C,Skin cancer,Soft tissue sarcoma,Spinal cancer,Stomach cancer,Vaginal cancer,Vulvar cancer,
    Testicular cancer,Tach Diseases,Leukemia,Liver cancer,Throat cancer,
    Syndrome Fibrodysplasia Ossificans ProgresSclerosis,Alzheimer's disease,Chronic Diarrhea,Copd,Parkinson,Als,Adrenocortical carcinoma  Infectious mononucleosis. 

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  17. Herpes Finally Gone, thanks to Dr. Utu for his Herbal Treatment.
    I had a sudden onset of cold sores and a new one was appearing each day. I was on primary immunosuppressant I noticed my body just can't fight the virus on its own. After five days of treatment and no success I suspected herpes I went for test and it was confirmed. God was my strength I met a doctor for treatment. He gave me Dr Utu's contact. I contacted him immediately, This medication was far amazing that within 24-48 hrs the blisters were crusting over. The swelling and redness was decreasing as well. I was on four weeks herpes medication which I completed before going for test. I went for herpes test and then again back to my doctor who confirmed me herpes negative it was really like a dream. What a relief! Feel Free to contact Dr Utu Email:- drutuherbalcure@gmail.com OR WhatsApp :- +2347032718477

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  18. Hello everyone, i'm Linda Harry from United State i was diagnosed with Parkinson Disease  for over 6 years which made me loose my job and my relationship with my Fiance after he discovered that i was having Parkinson, he departed from me, and i tried all my best to make him stays, but he neglected me until a friend of mine  from UK told me Great healer, who will restore my life back with his powerful healing herbal medicine. then he  sent me his email address to contact him- drimolaherbalmademedicine@gmail.com. and i quickly contacted him, and he said my condition can be solved, that he will treat the disease immediately only if i can accept trust on him and accept his terms and condition, i Agreed because i was so much in need of help by all means, so i did all he instructed me to do. And surprisingly after two weeks, He sent me a text, that i should hurry up to the hospital for a checkup, which i truly did, i confirm from my doctor that i am now ( PARKINSON NEGATIVE) my eyes filled with tears and joy, crying heavily because truly the disease deprived me of many things from my life, This is a Miracle, dr imoloa also uses his powerful herbal medicine to cure the following diseases:  lupus disease,  mouth ulcer,  mouth cancer, body pain, fever, hepatitis A.B.C.,   syphilis,  diarrhea,  HIV/AIDS,  Huntington's Disease,   back acne,  Chronic renal failure,   addison disease,  Chronic Pain,   Crohn's Disease,   Cystic Fibrosis,  Fibromyalgia,   Inflammatory Bowel Disease,  fungal nail disease, Lyme Disease, Celia disease, Lymphoma, Major Depression,  Malignant Melanoma,   Mania,  Melorheostosis,   Meniere's Disease,  Mucopolysaccharidosis , Multiple Sclerosis,  Muscular Dystrophy,  Rheumatoid Arthritis, Alzheimer's Disease, parkison disease, vaginal cancer, epilepsy,  Anxiety Disorders, Autoimmune Disease,   Back Pain,  Back Sprain,   Bipolar Disorder,  Brain Tumour,  Malignant,   Bruxism, Bulimia,  Cervical Disk Disease, cardiovascular disease, Neoplasms, chronic respiratory disease,  mental and behavioural disorder,     Cystic Fibrosis,   Hypertension, Diabetes, asthma,  Inflammatory autoimmune-mediated arthritis.  chronic kidney disease, inflammatory joint disease,  impotence,  feta alcohol spectrum,  Dysthymic Disorder,   Eczema, tuberculosis,  Chronic Fatigue Syndrome, constipation, inflammatory bowel disease, bone cancer, lung cancer. contact him on email- drimolaherbalmademedicine@gmail.com. and also on whatssap- +2347081986098

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  19. HSV1 & HSV2 Negative.
    Saying that, herpes virus is not curable is because you have not seen the right person to help you get rid of the virus. I testify because it's only someone who have experience this virus that konws what it means to be in this situation. After my marriage to Loe my hubby, i noticed one day that I had sudden Cold Sores in my genital part. I went for test and the doctor confirmed me being HSV2 positive.
    I felt my life and happiness with my hubby was finished. But to my greatest surprise my husband had contacted this virus and was later confirm HSV1 positive. I started noticing symptoms like cold sores, sore throat, fever blister, weakness of the body, runny nose, cough and finally the was a serious Outbreak. So I started looking for a remedy to our situation because the phamacytical drugs and the pains was too much for I and my hubby. I was looking for remedy online and different website when i saw a testimony about Dr. Akintunde and the herbal medicine that helped Erica to get rid of HSV2, I remembered my doctor told me the is no cure to this virus, I had to contact Dr. Akintunde on his WhatsApp number and told him about us and the virus, he promised to cure this virus with his herbal medicine. And he prepared four bottles of the herbal medicine and send to me through UPS delivery with instructions on how to take it. And only first week of my start, I noticed the outbreak and all the symptoms was off so, I told Dr. Akintunde about it and he said the medicine will eradicate the virus and boots my immune when i complete my medication. After I took the medicine I went back for retest and my doctor was surprised with my new status HSV2 negative my hubby also was cured. Thanks to Dr. Akintunde I am proud to say you safe our life and we remain greatful and we support your mission on humanity Sir, Do you experience such too?
    Tell Dr. Akin your health problem and be sure of total cure with his natural roots and herbs. Like Erica did testify to me I also testify for everyone who need help to be free from this inconveniencing virus, and any other health challenges you're having is curable believe me. All the best.
    Dr. Akintunde email and WhatsApp number below.
    Via email:-
    drakintundehomecare@gmail.com

    WhatsApp number:. +2347035245593

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  20. I am 29 years old and have been diagnosed with breast cancer, ease of treatment and a similar story, except for my first acceptance as a rejection of herbal medicine. I was not part of the Perseid movement and did not really build relationships with any of them, I just believed in their operation. I say this because it was during the use of Dr. Itua herbal medicine that I now attest that herbal medicine is real, the phytotherapy Dr. Itua heal my breast cancer which I suffered for 2 years. Dr. Itua herbal medicine is made of natural herbs, with no side effects, and easy to drink. If you have the same breast cancer or any type of human illness, including HIV / AIDS, herpes,Ovarian Cancer,Pancreatics cancer,bladder cancer, prostate cancer,  Glaucoma., Cataracts,Macular degeneration,Cardiovascular disease,Stroke,Autism,Lung disease.Enlarged prostate,Osteoporosis.Alzheimer's disease,Brain cancer,Esophageal cancer,Gallbladder cancer,Gestational trophoblastic disease,Head and neck cancer,Intestinal cancer,Kidney cancer,Melanoma,Mesothelioma,Multiple myeloma,Neuroendocrine tumors,Hodgkin lymphoma,Oral cancer,Ovarian cancer,Sinus cancer,,Soft tissue sarcoma,Spinal cancer,Stomach cancer,Testicular cancer,Throat cancer,Thyroid Cancer,Uterine cancer,Vaginal cancer,Vulvar cancer.psoriasis ,Tach Diseases,Lupus,Endomertil Cancer, cerebrovascular diseases,
    Dementia.lung cancer,skin cancer,testicular Cancer,Lupus, , LEUKEMIA, VIRUSES, HEPATITIS, INFERTILITY WOMEN / MAN,CONTACT EMAIL / WHATSAPP:  Or  drituaherbalcenter@gmail.com/ +2348149277967

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  21. Grateful to Dr LOSA for all his help for my life, my partner was having Herpes Simplex Virus, and we were planing on getting married on early December, when we decided to get ourselves tested first and we found out that my Girlfriend was HSV 2 Positive, my Girlfriend was so unhappy, because this was a barrier for us to get married, so i went out to search out a remedy for my partner, and it was so surprising how Dr LOSA has been a blessing and healing to the masses, after reading about his work on a blog i immediately emailed him: dr.losaherbalhome@gmail . com and he wrote back to me that my Girlfriend will be OK and that we we get married this same year, i couldn't believe it, after doing all that is needed to be done, i was surprise that after 2weeks of using his medicine my Girlfriend went to the doc and was diagnose negative. For more info contact his
    Whatsapp +2349056464736.OR
    email dr.losaherbalhome@gmail . com and you will get your illness cure and also beware of scams Good Luck
    He cure listed diseases
    CANCER
    HEPATITIS A AND B
    DIABETIC.
    HERPES

    ReplyDelete
  22. Call Dr. Jakiki for urgent and fast love spell +1 (304) 441-7224 or email him Spellcasthome@gmail.com

     I lost my husband to another woman,after 4 years of marriage . We had a lovely marriage but he started a relationship with a co worker who chased after him . He is living away near his work and he refused to talk to me or to come home . I was so devastated and found it hard to cope. I became very worried and needed help. As I was browsing through the internet one day, I came across a comment by Amber that suggested that Dr Jakiki helped her solve her marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he did a spell for me. 2 days later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Jakiki. If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. I give you 100% guarantee that he will help you. His website: http://Spellcasthome.website2.me

    His email Spellcasthome@gmail.com 

    Call him +1 (304) 441-7224

    ReplyDelete
  23. Call Dr. Jakiki for urgent and fast love spell +1 (304) 441-7224 or email him Spellcasthome@gmail.com

     I lost my husband to another woman,after 4 years of marriage . We had a lovely marriage but he started a relationship with a co worker who chased after him . He is living away near his work and he refused to talk to me or to come home . I was so devastated and found it hard to cope. I became very worried and needed help. As I was browsing through the internet one day, I came across a comment by Amber that suggested that Dr Jakiki helped her solve her marital problems, restore broken relationships and so on. So, I felt I should give him a try. I contacted him and he did a spell for me. 2 days later, my husband came to me and apologized for the wrongs he did and promise never to do it again. Ever since then, everything has returned back to normal. I and my family are living together happily again.. All thanks to Dr Jakiki. If you need a spell caster that can cast a spell that truly works, I suggest you contact him. He will not disappoint you. I give you 100% guarantee that he will help you. His website: http://Spellcasthome.website2.me

    His email Spellcasthome@gmail.com 

    Call him +1 (304) 441-7224

    ReplyDelete
  24. What a wonderful and a straight forward spell caster that has brought back joy and happiness into my life! Am giving this testimony because am so happy, I want to thank Dr. Osasu for the great thing He has done in my life , He brought happiness back to my life, I never believed in spell casters until my life fell apart when my lover of 6 years decided to call it quit almost when we wanted to get married. I was so emotional breakdown to the extent i could not do anything reasonable again, after 2months in pain before an old friend of mine introduced me to a spell caster on line called Dr Osasu, this was after I have been scammed by various fake spell casters. I was introduced me to Dr Osasu a true Spell Caster. In less than 24 hours i saw wonders, my lover came back to me and my life got back just like a completed puzzle, and after 1month later we got married and it was just like a dream to me because i thought i had lost him forever. Thank you Dr. Osasu for helping me but most of all, Your Honesty and Fast Accurate Results. email: Drosasu25@gmail.com WhatsApp Number: +2347064365391

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