Wednesday, 26 October 2016

Metabolic Therapeutics: the science behind exploiting weaknesses in cancer metabolism.

In the third episode of the Beating Brain Cancer podcast we had the great pleasure of interviewing Dr. Angela Poff, Research Associate in the Department of Molecular Pharmacology and Physiology at the University of South Florida.

Dr. Angela Poff

Dr. Poff works in the Laboratory of Nutritional and Metabolic Medicine under the mentorship of Dr. Dominic D'Agostino. Her research focuses on the development and testing of non-toxic metabolic therapies for cancer and neurological disorders.

Dr. Poff's research focuses primarily on vivo research using rodent models with metastatic cancer derived from human glioblastoma cell lines.

The aim of her work is to observe the effects of nutritional ketosis, exogenous ketones and hyperbaric oxygen therapy and outline the underlying synergistic anti-cancer mechanisms behind these treatments.

The audio recording of this interview is available here:

Wednesday, 19 October 2016

Cannabinoids and Cancer: a hot topic often surrounded by controversies

I recently had the privilege of interviewing Dr. Wai Liu at St. George's University Hospital to talk about cannabinoids and cancer. More details of the interview can be found on my website here:

Monday, 26 September 2016

Exercise updates, photodynamic therapy and the iKnife.

Exercise was a huge seizure trigger for me since acquiring brain tumour related epilepsy. Over time my seizure threshold has improved thanks to a high DHA ketogenic diet. Yesterday I was able to run for the first time in 4 years. I managed 20 minutes plus a light resistance workout. Today I ran 30 minutes without stopping at a decent pace. 

I never thought this would be possible when I look back at where I've come, suffering those horrible grand mal seizures and now being on no medication with complete seizure control. 

Never forget that our brains are made of fat and cholesterol. As I have written on several occasions, in and around malignant brain tumours we see dysregulated lipid composition when compared to healthy, disease free brains. This is often how neurosurgeons actually identify tumour tissue for resection, as described from the study below and from use of the iKnife, which identifies malignant tissue and can be combined with a form of photodynamic therapy. 

Photodynamic therapy- 5-ALA:
The tissue that 'glows' represents diseased tissue and the differences in lipid composition are clear. The smoke coming from the iKnife during resection of the tumour can analyse the lipid composition of tissue using a mass spectrophotometer

Epilepsy and neurodegerative diseases can all me managed more effectively with manipulation of dietary fatty acids. I believe this has been an essential part of my strategy to manage my disease and the epilepsy I have acquired as a result. I have been fine-tuning this approach over time and I have regular blood tests to monitor the efficacy of this approach. I wrote about this in more detail in my post on fatty acids and brain tumours which can be found here: 

The iKnife:

Sunday, 7 August 2016

Mornings are fun.

Despite exercise being a seizure trigger I enjoy my morning walks. Its at a pace which doesn't overstimulate my brain and I find it very calming. Walking allows me to reflect and to enjoy natural beauty. We have so many beautiful green spaces in this country and its a beautiful, sunny day today. The shorts will be on later and I'll do some sunbathing to top up the vitamin D. :)

Friday, 5 August 2016

Aspirin for brain cancer. Evaluating efficacy

Some new videos on my Youtube channel evaluating the efficacy of different forms and doses of aspirin for brain cancer management and as a potential anticonvulsant:

I'm trying to get used to recording presentations using my computer. I'm not sure how to edit videos yet without hassle but I tried my best here. I hope people find this interesting, there are 3 videos in the series.

Aspirin for brain cancer- part 1

Aspirin for brain cancer- part 2

Aspirin for brain cancer- part 3

Wednesday, 20 July 2016

Thursday, 14 July 2016

New insights from a new website?

I have created a website to provide a place to share data I have collected to support a metabolic protocol to managing brain cancer. I hope that this information can empower patients by providing the resources they need to take control of their treatment, whatever that may be.

I have decided to name it:

'Metabolic Therapy Resources for Brain Cancer Management'

This website will grow and evolve as I gather more information and when I have time to update it. Feel free to contribute with additional materials others might find useful in their search for evidence based metabolic approaches to this devastating disease. Please share with anybody you know who has been diagnosed with a brain tumour of any grade and type.