Tuesday, 25 August 2015

"Sugar feeds cancer" is far too simplistic and doesn't at all give you the full story.

Glutamine. Everyone forgets about glutamine...

'... in many cancer cells, glutamine is the primary mitochondrial substrate and is required to maintain mitochondrial membrane potential and integrity as well as support of the NADPH production needed for redox control and macromolecular synthesis.'  



This is why a restricted ketogenic diet for cancer management must restrict protein. Therapeutic fasts can also be  potentially very useful. 
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4 comments:

  1. Simon25 August 2015 at 07:41

    Hi Andrew,

    it seems that even without protein restriction a ketogenic diet is supposed to inhibit glutaminolysis through PPAR α activation by free fatty acids.

    "PPAR α mediated stimulation of mitochondrial fatty acid oxidation and ketogenesis with simultaneous reduction of glucose and glutamine consumption"
    http://www.ncbi.nlm.nih.gov/pubmed/21133850

    It seems to work synergistically. Protein restriction will inhibit glutaminolysis via less activation of mTORC1, while carbohydrate restriction will inhibit mTORC1 via activation of AMPK.

    See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988521/figure/Fig2/

    From this perspective it's not the so much the limitation of substrates per se (glucose, amino acids) that leads to the anti-cancer properties, but the regulatory effects these substrates have in terms of signalling. Assuming of course that the cancer cells in question will still heed these signals.

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