Tuesday, 25 August 2015

"Sugar feeds cancer" is far too simplistic and doesn't at all give you the full story.

Glutamine. Everyone forgets about glutamine...

'... in many cancer cells, glutamine is the primary mitochondrial substrate and is required to maintain mitochondrial membrane potential and integrity as well as support of the NADPH production needed for redox control and macromolecular synthesis.'  

This is why a restricted ketogenic diet for cancer management must restrict protein. Therapeutic fasts can also be  potentially very useful. 


  1. Hi Andrew,

    it seems that even without protein restriction a ketogenic diet is supposed to inhibit glutaminolysis through PPAR α activation by free fatty acids.

    "PPAR α mediated stimulation of mitochondrial fatty acid oxidation and ketogenesis with simultaneous reduction of glucose and glutamine consumption"

    It seems to work synergistically. Protein restriction will inhibit glutaminolysis via less activation of mTORC1, while carbohydrate restriction will inhibit mTORC1 via activation of AMPK.

    See: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3988521/figure/Fig2/

    From this perspective it's not the so much the limitation of substrates per se (glucose, amino acids) that leads to the anti-cancer properties, but the regulatory effects these substrates have in terms of signalling. Assuming of course that the cancer cells in question will still heed these signals.

  2. My Wife Stage IV breast cancer and MS has just been cured with the cannabis oil gotten from DR.PATRICK OSCAR cannabis oil is great medication. To hell with the government and their insane policy, we have a medication that is hundred percent assured to cure cancer and you don't need to spend so much money on anymore on chemo, radiation or surgeries that wouldn’t work. Where to purchase, contact via: (drpatrickoscar@yandex.com) My family is now a brand new one, so stop your worries and go get your medication and set the family free of the deadly disease that hold no respect to family harmony. Make your health a better one by using cannabis oil in your everyday life. contact Dr.Patrick on: drpatrickoscar@yandex.com for all type of cancer cure

    From USA.