Tuesday 7 March 2017

Branched chain amino acids, the ketogenic diet pill, and ketosis

Recently I have been combining exogenous ketones with BCAAs on my restricted protein ketogenic diet protocol to see how I react over time. Nutritional ketosis produces an increased ratio of plasma branched chain amino acids to aromatic amino acids which is one of its main proposed mechanisms of action for seizure control. 




It has been suggested that the high ratio of plasma BCAAs/ARAAs could be useful for epileptics as it results in decreasing ARAAs- (ARAAs supposedly increase the excitability potential of the brain entering the central nervous system (Jirapinyo et al., 2004)). This shift resulting in a rise of BCAAs to ARAAs means that a state of ketosis will decrease the excitability potential of the brain and increase seizure threshold. The brain becomes more resilient to stress you could say and brain chemistry in general is more balanced as a result. I feel pretty good today but its just one day, one experiment, and the type I am taking also includes resveratrol and L-carnitine (which may have its own benefits). Resveratrol readily crosses the blood brain barrier and modulates the Wnt signalling pathway to impair glioma stem cell proliferation and inhibit angiogenesis (Cilibrasi et al., 2017)

I have been taking the BCAAs at the same time as my exogenous ketones because I have held the belief for a while now that exogenous ketones could improve drug delivery to the brain (much like the combination of aspirin and caffeine) and research already suggests that brain amino acid metabolism is more efficient in a ketotic state (Yudkoff et al., 2007). 

These branched chain amino acids compliment ketogenesis nicely and leucine and lysine in particular are strictly ketogenic amino acids which have shown potent anticonvulsant effects. Its complicated, I know, and the ratio of individual amino acids are important, so I'm still learning and testing blood ketones and blood glucose to assess efficacy.

I am particularly interested in this amino acid supplement from Dr. Heinz Reinwald, who has used it in some very interesting studies for the metabolic management of cancer and to compliment immunotherapy treatments such as in the study below.

Amino acid product and study:

https://www.drreinwald.de/fileadmin/media/downloads/MAP-Product_Info-Basic-E-Web.pdf


http://thescipub.com/abstract/10.3844/ajisp.2016.91.98


IMG- Glucogenic and Ketogenic amino acids:
https://en.wikipedia.org/wiki/Gluconeogenesis

The effects of all this, and nutritional ketosis in general, can be similar to that of the 'ketogenic diet pill' developed by researchers in Japan. The drug, sitipentol, works primarily by enhancing central Gaba neurotransmission and by inhibiting lactate dehydrogenase, an important enzyme involved in the energy metabolism of neutrons (Sada et al., 2015)

IMPORTANT!!! In cancer, lactate dehydrogenase expression is enhanced as a result of the Warburg Effect (Hirschhaeuser, Sattler, and Mueller-Klieser, 2011) so sitipentol could indeed be very useful not just for seizure control of drug resistant epilepsy, but also to compliment a metabolic protocol for cancer management to take advantage of this metabolic defect. 


IMG- Targeting Lactate Dehydrogenase A inhibits tumourigenesis and tumour progression in mouse models:
(Xie et al., 2014)
The side effects could be irritating, as with other anticonvulsants, but if you have active cancer the pay-off would be worth it in my opinion and I would take the drug in a heartbeat if I ever have a recurrence. It could be taken in cycles. I have back up plans as I have mentioned a few times, and this is near the top of my list of things I would add to my protocol to hit the cancer hard if the situation arises (hopefully not). 

I believe it would likely be effective at therapeutic doses that go beyond seizure control. I would even be more comfortable taking stiripentol than metformin for brain cancer management even though I think they both show great potential. I would simply be more confident of stiripentol offering the specific neurological effects I would be hoping for despite the side effects. I am not entirely convinced that metformin crosses the blood brain barrier at appreciable amounts despite its ability to lower blood glucose so I see sitipentol as being potentially more suitable for brain cancer specifically in theory. It just makes sense to me.


Stiripentol by Diatomit enhances beneficial effects of the therapeutic ketosis for cancer management by inhibiting lactate dehydrogenase and offers neuroprotection and increased seizure threshold by enhancing central Gaba neurotransmission: http://www.diacomit.eu/en/64-check

I had already undertaken extensive research into leucine after learning about its very promising results for drug resistant epilepsy in animals. I wrote a long article on this a while ago, but it was deleted which is a little frustrating, however there is a decent summation here of the potential of these ketogenic amino acids, even in isolation for seizure control.- https://www.epilepsy.org.uk/news/news/amino-acid-good-rescue-medication-64819

Supplementation with L-carnitine may be especially useful for patients taking valproic acid (Epilim) as an anticonvulsant because it can result in hormonal dysregulation in both females AND males. These effects in males are rarely documented or even discussed. Men taking VPA display significantly lower free carnitine/total carnitine but it also makes your sperms weaker swimmers (lower motility), lowers testosterone, and raises insulin and C-peptide concentrations (YIKES!) (Røste et al., 2005)

Carnitine also aids fatty acid metabolism of course being an essential cofactor required for long chain fatty acids to enter mitochondria. It aids oxidation of palmitic acid (Seim, Kiess and Richter, 2002) so one could potentially argue (I don't know, just a theory) that maybe that if this palmitic acid is used and not stored as body fat (which would promote systemic inflammation), that these studies suggesting palmitic acid promotes carcinogenesis (Pasqual et al., 2017) may be invalidated from a well constructed dietary perspective. It is also worth noting that the study looked at CD36, which is a fatty acid receptor for oxidised low density lipoprotein (the 'bad' cholesterol), which is often linked to atherosclerosis (Endemann et al., 1993) and shouldn't be a problem on a well structured ketogenic diet. Quite the opposite in fact.


IMG- Oxidation of fatty acids: carnitine (Flanagan et al., 2010)

People have different opinions on this, and it is likely that it is actually the ratio of LDL cholesterol and HDL cholesterol is more important or simply HDL on its own (if its too low this is the main problem it seems). On a well structured ketogenic diet LDL cholesterol is unlikely to change much (it may be a little elevated but particle size is the important consideration) but high density lipoprotein (the 'good' cholesterol), usually increases and insulin is normalised. 

This would mean that CD36 is unlikely to be expressed to respond, forming a 'foam cell' as shown below. This is called a foam cell because macrophages are recruited to the location of these fatty deposits on blood vessel cell walls. It is a pro-inflammatory response causing the cell to be filled with lipids and this action creates a 'foamy' appearance. 


IMG- Foam Cell https://en.wikipedia.org/wiki/Foam_cell
A well structured ketogenic diet is anti-inflammatory and also is unlikely to increase thrombosis and platelet aggregation. Risk factors for cardiovascular disease for example are actually improved being on a ketogenic diet, as is the lipid profile as a result. The ketogenic diet improves triglyceride levels, HDL, and LDL particle size- measures that have been seen as indicating risk. More information with a comprehensive list of references can be found here:



IMG- (Lüscher et al., 2014)

IMG- https://www.spectracell.com/clinicians/products/lpp/

The ketogenic diet is about using fat for energy and it is excess carbohydrates and trans fats which will cause this type of fat to be stored, creating inflammatory responses. I remain unconvinced that palmitic acid from foods such as ghee and coconut oil will promote carcinogenesis, especially when the fatty acid profile is balanced appropriately and the diet is personalised. Palmitic acid from grass fed and grain fed animals may also be different of course, just a thought. I am no expert of course (I'm always learning, nobody is a true expert), but the basic idea seems to make sense to me.


IMG- (St-Pierre et al., 2017)
Other anti-epileptic drugs have similar issues. As with everything though, it is always my belief that we can adjust these variables to bring endocrine functioning back to normal parameters AND allow the drugs to do exert their positive effects IF it is working for the patient to maintain seizure control. I was on VPA (Epilim) at one point when I took AEDs, and it does have survival benefits, but it is my firm belief that any micronutrient deficiencies the medication causes and any negative hormonal responses must be accounted for to achieve the best results not only for seizure control, but also quality of life and potential survival for improved survival.

Maybe I'll have amazing cognitive abilities and be superhuman in some way. It would be good to just feel more normal as I still feel like crap a lot of the time. Telekinesis would be pretty fun though or the ability to read a whole book on a complicated subject in a single day. Kind of like Doctor Strange, that was a cool film, enjoyed it. I like superheroes with intelligence rather than the meathead types.


IMG- http://www.twincities.com/2016/11/03/doctor-strange-review/

References:

Acharjee, S., Boden, W.E., Hartigan, P.M., Teo, K.K., Maron, D.J., Sedlis, S.P., Kostuk, W., Spertus, J.A., Dada, M., Chaitman, B.R. and Mancini, G.J., 2013. Low levels of high-density lipoprotein cholesterol and increased risk of cardiovascular events in stable ischemic heart disease patients: a post-hoc analysis from the COURAGE Trial (Clinical Outcomes Utilizing Revascularization and Aggressive Drug Evaluation). Journal of the American College of Cardiology62(20), pp.1826-1833.

Cilibrasi, C., Riva, G., Romano, G., Cadamuro, M., Bazzoni, R., Butta, V., Paoletta, L., Dalprà, L., Strazzabosco, M., Lavitrano, M. and Giovannoni, R., 2017. Resveratrol Impairs Glioma Stem Cells Proliferation and Motility by Modulating the Wnt Signaling Pathway. PLOS ONE12(1), p.e0169854.

Endemann, G., Stanton, L.W., Madden, K.S., Bryant, C.M., White, R.T. and Protter, A.A., 1993. CD36 is a receptor for oxidized low density lipoprotein. Journal of Biological Chemistry268(16), pp.11811-11816.

Flanagan, J.L., Simmons, P.A., Vehige, J., Willcox, M.D. and Garrett, Q., 2010. Role of carnitine in disease. Nutrition & metabolism7(1), p.30.

Hirschhaeuser, F., Sattler, U.G. and Mueller-Klieser, W., 2011. Lactate: a metabolic key player in cancer. Cancer research71(22), pp.6921-6925.

Jin, J.X., Lee, S., Taweechaipaisankul, A., Kim, G.A. and Lee, B.C., 2017. Melatonin regulates lipid metabolism in porcine oocytes. Journal of Pineal Research62(2).

Jirapinyo, P., Kankirawatana, P., Densupsoontorn, N., Thamonsiri, N. and Wongarn, R., 2004. High plasma branched-chain amino acids: aromatic amino acids ratio in children on the ketogenic diet: a mechanism in controlling epilepsy. JOURNAL-MEDICAL ASSOCIATION OF THAILAND87(4), pp.432-437.


Lüscher, T.F., Landmesser, U.L.F., von Eckardstein, A. and Fogelman, A.M., 2014. High-density lipoprotein. Circulation research114(1), pp.171-182.

Pascual, G., Avgustinova, A., Mejetta, S., Martín, M., Castellanos, A., Attolini, C.S.O., Berenguer, A., Prats, N., Toll, A., Hueto, J.A. and Bescós, C., 2017. Targeting metastasis-initiating cells through the fatty acid receptor CD36. Nature541(7635), pp.41-45.

Prospective Studies Collaboration, 2007. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55 000 vascular deaths. The Lancet370(9602), pp.1829-1839.


Røste, L.S., Taubøll, E., Mørkrid, L., Bjørnenak, T., Saetre, E.R., Mørland, T. and Gjerstad, L., 2005. Antiepileptic drugs alter reproductive endocrine hormones in men with epilepsy. European journal of neurology12(2), pp.118-124.

Sada, N., Lee, S., Katsu, T., Otsuki, T. and Inoue, T., 2015. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science347(6228), pp.1362-1367.

Schwalb, M. et al. 2016. Clinical Observation of a Novel, Complimentary, Immunotherapeutic Approach based on a Ketogenic Diet, Chondroitin Sulfate, Vitamin D3, Oleic Acid and a Fermented Milk and Colostrum Product. American Journal of Immunology. Vol 12(4). pp.91-8.

Seim, H., Kiess, W. and Richter, T., 2002. Effects of oral L-carnitine supplementation on in vivo long-chain fatty acid oxidation in healthy adults. Metabolism51(11), pp.1389-1391.

St-Pierre, V., Courchesne-Loyer, A., Vandenberghe, C., Hennebelle, M., Castellano, C.A. and Cunnane, S.C., 2017. Butyrate is more ketogenic than leucine or octanoate-monoacylglycerol in healthy adult humans. Journal of Functional Foods32, pp.170-175.


Xie, H., Hanai, J.I., Ren, J.G., Kats, L., Burgess, K., Bhargava, P., Signoretti, S., Billiard, J., Duffy, K.J., Grant, A. and Wang, X., 2014. Targeting lactate dehydrogenase-a inhibits tumorigenesis and tumor progression in mouse models of lung cancer and impacts tumor-initiating cells. Cell metabolism19(5), pp.795-809.

Yudkoff, M., Daikhin, Y., Melø, T.M., Nissim, I., Sonnewald, U. and Nissim, I., 2007. The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect. Annu. Rev. Nutr.27, pp.415-430.



22 comments:

  1. > I remain unconvinced that
    > palmitic acid from foods such as ghee and coconut
    > oil will promote carcinogenesis, especially when
    > the fatty acid profile is balanced
    > appropriately and the diet is personalised.

    Hi again Andrew!

    You've mentioned on twitter that your tolerance to MCT oil
    (through the last 2-3 years, I assume) has greatly increased.

    What kind of intolerance it was in the early days of ketogenic-style diet?
    i.e. did it come in the form of increased brain inflammation?

    I'am asking this because I'am currently is very intolerant to coconut/MCT oils,
    and digging deeper I've found that oil's fatty acids possess huge
    antibacteral properties.

    Every time I take Coconut Oil my photosensitivity got raised a bit,
    followed by a drop in blood pressure further followed by greatly increased fatigue/malaise
    and increased brain inflammation(anxiety, racing/rapid thoughts, rage)
    - all classic signs of increased level of blood endotoxins(endotoxemia) and
    proinflammatory cytokines, pointed to infected brain/body.

    I'am wondering what if during your ketogenic years your brain/body
    got cleared out of chronic infections(excessive glucose/excessive tryptophan-dependent bugs)
    and yours greatly increased tolerance to MCT(I assume to CO too) is a sign of it?

    Best Wishes, Dmitry

    ReplyDelete
    Replies
    1. Hi Dmitry,

      Yes, I experienced this early on with only a couple of teaspoons and now I find I can tolerate a good few tablespoons! Such a difference, I don't know why this is but would love to know. Some things remain mysteries and I wish I had been able to have more tests to see what has been going on over time neurologically but unfortunately it costs a lot of money and I have negative funds at the moment.

      I hope you are able to find answers, its interesting how I can now tolerate many foods which triggered these severe inflammatory responses for me. It also used to give me diarrhoea even at small doses and this doesn't happen anymore.

      Delete
    2. Oligopeptide-34 is a small protein molecule (also known as a peptide) consisting of 13 amino acids strung together to create a highly efficient and active molecule that addresses melanin formation. Oligopeptide-34

      Delete
    3. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346



      i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
      or
      call/whatsapp:+2349057261346

      Delete
    4. The doctors said Herpes virus do not have medical cure because the virus is capable of hiding within the human cells, it remains protected from your immune system. Herpes isn’t a special virus – your immune system has the tools to fight it back. But because it is able to lay dormant in protected cells, your immune system is unable to remove it from your body,But with strong reactive herbal medication is capable of getting rid of the virus gradually and totally from your body without damaging any of your cells,natural herbs kills the virus totally not just reducing the out break. Get natural herbs cure Email DR. VOODOO at voodoospelltemple66@gmail.com Add Dr voodoo on whatsApp +2348140120719

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  2. Hello Andrew! I am very inspired by your story. I would like to ask you some questions - do you have an email to do so?

    ReplyDelete
  3. Volek showed that circulating saturated fats depended on carbs. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113605
    A few weeks ago I read ectopic fat deposition depends more on VLDL which depends on carbs

    ReplyDelete
  4. Hi Andrew, Wow I saw your interview with Ivor Cummins yesterday and I have to take my hat off to you ... you have really turned over the rocks to get yourself well again. So inspiring. I don't know how else to contact/communicate with you. I do not have any serious ailments (except a broken leg last week after a fall off my bike!!) but I note your comment about lack of magnesium and the type you were taking. I felt the need to tell you about Dr Dean's absolutely fantastic Remag if you haven't already heard about it. Following is an extract from her book "Invisible Minerals" which says it all when it comes to Magnesium.

    "Pico-Ionic Magnesium –ReMag ReMag consists of stabilized magnesium ions that are small enough in size that they are fully absorbed at the cellular level. The ionic charge allows ReMag to be attracted to the cells that require it. Because it is fully absorbed, ReMag has no laxative effect. Joseph B. Marion in his Anti-Aging Manual (1999) says “Most minerals (from food) are 8-12% absorbable, chelated minerals are 40% absorbable, and liquid Angstrom minerals are 99% absorbable, being 7,000 times smaller than Red blood cells, 1 million times smaller than a colloidal mineral, smaller than ionic, with negative-charge for added absorption.” Angstrom and Pico-Ionic minerals are similar in size, which means they are 99% absorbed at the cellular level. The difference between angstrom magnesium and ReMag is in concentration. Angstrom minerals are concentrated to 3,000ppm. ReMag is vastly more concentrated at 60,000ppm. Thus it is 20 times more effective."

    I believe you can download her book for free if you go to her web page rnareset.com. I have no connection to Dr Dean ... I just take her supplements which speak for themselves.

    Good luck with your studies, enquiries and most of all ... your health. Bon courage!!

    ReplyDelete
  5. Not sure if you are familiar with these two organizations which may be helpful regarding Ketosis and seizures
    https://www.charliefoundation.org http://www.matthewsfriends.org

    ReplyDelete
  6. As a sign of gratitude for how my wife was saved from CANCER, i decided to reach out to those still suffering from this.
    My wife suffered cancer in the year 2013 and it was really tough and heartbreaking for me because she was my all and the symptoms were terrible, she always complain of abnormal vaginal bleeding, and she always have pain during sexual intercourse. . we tried various therapies prescribed by our neurologist but none could cure her. I searched for a cure and i saw a testimony by someone who was cured and so many other with similar body problem, and he left the contact of the doctor who had the cure to cancer . I never imagined cancer. has a natural cure not until i contacted him and he assured me my wife will be fine. I got the herbal medication he recommended and my wife used it and in one months time he was fully okay even up till this moment he is so full of life. cancer. has a cure and it is a herbal cure contact the doctor for more info on drwilliams098765@gmail.com on how to get the medication. Thanks for reading my testimony.

    ReplyDelete
  7. I wrote story about my HPV infection that spread through entire body and found that you can actually make a progress without supplements or any conventional or alternative therapies by using natural sources and that is oxygen. Don't spend thousands of dollars or euros for books or medications because the only thing you need to do is to spend a lot of time outdoor and put loads of oxygen into your cells. With this easy way you only need to add quality natural food and you're done. If you want you can check my blog at https://virushpvblog.wordpress.com/ but use slovenian to english translation, it is easy to understand.

    ReplyDelete
  8. This comment has been removed by the author.

    ReplyDelete
  9. Am really grateful and thankful for what moonlightspellcaster@gmail.com has done for me and my family. i have be suffering from HERPES for good three years with no solution, the diseases almost took my life and because I was unable to work and I was also loosing lots of money for medication, but one faithful day when I went online, I met lots of testimonies about this great man so I decided to give it a try and to God be the glory he did it. If you need his help or you also want to get cured just the way I got mine, just email him : moonlightspellcaster@gmail.com and get your healing. He has cure for other deadly diseases like Herpes, Hiv, Hepatitis,ALS
    THESE ARE THE THINGS Dr. MOONLIGHT. . HERPES . HIV/AIDS . CANCER
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    5,Adverse Childhood Experiences,
    6,Acquired Immune Deficiency syndrome (HIV/AIDs)
    7,Trypanosomiasis(Sleeping Sickness)
    8,Asthma
    9,stomach Infection
    10,Goloria
    11,Pytogen(Dust Infection
    12,Nemonia e.t.c.
    You can contact him via: Email: moonlightspellcaster@gmail.com

    ReplyDelete
  10. Please beware of many fake Dr here I lost $4600 trying to look for a love spell until I meet mama Anita who get my ex husband back in 24hours if you need similar help her contact email is mamaanita.lovespellsolution@gmail.com

    ReplyDelete
  11. In stock products can be shipped out within 3-5 business days upon receipt of customers' purchase order. Amino Acid Abbreviations

    ReplyDelete
  12. HSV1 & HSV2 Negative.
    Saying that, herpes virus is not curable is because you have not seen the right person to help you get rid of the virus. I testify because it's only someone who have experience this virus that konws what it means to be in this situation. After my marriage to Loe my hubby, i noticed one day that I had sudden Cold Sores in my genital part. I went for test and the doctor confirmed me being HSV2 positive.
    I felt my life and happiness with my hubby was finished. But to my greatest surprise my husband had contacted this virus and was later confirm HSV1 positive. I started noticing symptoms like cold sores, sore throat, fever blister, weakness of the body, runny nose, cough and finally the was a serious Outbreak. So I started looking for a remedy to our situation because the phamacytical drugs and the pains was too much for I and my hubby. I was looking for remedy online and different website when i saw a testimony about Dr. Akintunde and the herbal medicine that helped Erica to get rid of HSV2, I remembered my doctor told me the is no cure to this virus, I had to contact Dr. Akintunde on his WhatsApp number and told him about us and the virus, he promised to cure this virus with his herbal medicine. And he prepared four bottles of the herbal medicine and send to me through UPS delivery with instructions on how to take it. And only first week of my start, I noticed the outbreak and all the symptoms was off so, I told Dr. Akintunde about it and he said the medicine will eradicate the virus and boots my immune when i complete my medication. After I took the medicine I went back for retest and my doctor was surprised with my new status HSV2 negative my hubby also was cured. Thanks to Dr. Akintunde I am proud to say you safe our life and we remain greatful and we support your mission on humanity Sir, Do you experience such too?
    Tell Dr. Akin your health problem and be sure of total cure with his natural roots and herbs. Like Erica did testify to me I also testify for everyone who need help to be free from this inconveniencing virus, and any other health challenges you're having is curable believe me. All the best.
    Dr. Akintunde email and WhatsApp number below.
    Via email:-
    drakintundehomecare@gmail.com

    WhatsApp number:. +2347035245593

    ReplyDelete
  13. Hi everyone I'm Mrs Katrina Bennett, My husband divorced me 2 years ago to live with another woman and i have tried have him back but i could not, so i try to do many things to get him back and he refuse to come back. One faithful Friday morning, I visit a forum for tips on how to get your Ex back and there i saw a lady testifying on how Dr.alusi helped her to get her husband back after he was tie down with a spell by another woman. Although I never believed in spiritual work I reluctantly tried him because I was desperate and i contact him and explain my problems to him, to my greatest surprise Dr.alusi helped me to bring back my husband after 5days and now my relationship is more perfect just as he promised. Getting your ex back permanently does not only bring back someone you love but it will also reunite your lovers feelings. My husband now treats me like a Queen and always says he loves me all the time. If you are passing through difficulties in your relationship, Doctor alusi can help solve marital problems, restore broken relationships and some other things.I can assure he's highly potent and reliable. Email him for urgent help [dr.alusistanley@gmail.com] or +2348146050373.

    ReplyDelete
  14. my partner and I have been trying for a baby for over two years now, We were going to a fertility clinic for about 5 months before somebody at baby center told us to contact this spell caster who is so powerful, We contacted him at this email; babaka.wolf@gmail.com or Facebook at priest.babaka , for him to help us, then we told him our problem, he told us that we will conceive once we follow his instructions ,but after two years of trying we were at a point where we were willing to try anything. And I'm glad we came to Priest Babaka, Because his pregnancy spell cast and herbal remedy help us, and I honestly believe him, and his gods really helped us as well, I am thankful for all he has done. contact him via email: babaka.wolf@gmail.com or Facebook at priest.babaka if you are trying to have a baby or want your lover back. he has powers to do it, he has done mine










    my partner and I have been trying for a baby for over two years now, We were going to a fertility clinic for about 5 months before somebody at baby center told us to contact this spell caster who is so powerful, We contacted him at this email; babaka.wolf@gmail.com or Facebook at priest.babaka , for him to help us, then we told him our problem, he told us that we will conceive once we follow his instructions ,but after two years of trying we were at a point where we were willing to try anything. And I'm glad we came to Priest Babaka, Because his pregnancy spell cast and herbal remedy help us, and I honestly believe him, and his gods really helped us as well, I am thankful for all he has done. contact him via email: babaka.wolf@gmail.com or Facebook at priest.babaka if you are trying to have a baby or want your lover back. he has powers to do it, he has done mine

    ReplyDelete
  15. My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end I almost committed suicide, I was emotionally down for a very long time. Thanks to a spell caster called Dr Mark, which I met online. On one faithful day, as I was browsing through the internet,I came across a lot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. I also came across one particular testimony,it was about a woman called Alandre,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mark e-mail address. blessedlovetemple@gmail.com After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48 hours, my husband came back to me. We solved our issues, and we are even happier than before. Dr Mark is really a gifted man and I will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. blessedlovetemple@gmail.com anytime, he might be the answer to your problems.

    ReplyDelete
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