Thursday, 8 March 2018

L-Carnitine, ketolytic enzymes and therapeutic ketogenic diets for cancer management.

L-Carnitine plays an absolutely vital role in the metabolism of fatty acids.

Mo Farah is recently, somewhat controversially been pruported to have had an injection of L-Carnitine before the 2014 London Marathon for performance gains. It is worth noting that Mo Farah is an endurance athlete, so fat is the predominant fuel source. Fat oxidation rate is high so if you can sustain this for a longer period of time you can improve limits of exhaustion.

Carnitine shuttle (1)
This IV administration by Mo Farah is now being seen by the media in this country as 'cheating within the rules' with increased scrutiny recently of 'marginal gains' in athletic performance and sport in general after the cycling 'scandal' with Team Sky riders making the most of Therapeutic Use Exemptions (TUEs) that are known to improve performance for endurance athletes.



What helps athletes often has great potential for cancer patients- ie. infusion of nutrients, certain drugs, nutritional supplements, hyperbaric chambers, cold induced thermogenesis, infrared saunas, etc.

It is interesting....

Like Mo Farah I also take L-Carnitine because it ensures efficient transfer of long-chain fatty acids to mitochondria for subsequent β-oxidation. The brain has an abundance of mitochondria and if you subscribe to the mitochondrial defect theory of cancer as I do its kind of a no brainer (pun intended) that you would want to make the most of everything you can do to do try and restore mitochondrial function here. This can potentially be very beneficial for ensuring that ketone bodies produced during fasting, or fats on the ketogenic diet actually get used so that we can attempt to attain more healthy mitochondria.

This is what I take
There is exhaustive evidence showing how supplementation with L-Carnitine could benefit cancer patients, mostly for reducing general fatigue during chemotherapy (2) but also for normalising lipid metabolism for more general health (3). Anti-dementia effects have been proposed and suggested when co-administering L-Carnitine with medium chain triglycerides (MCTs) and other agents (5, 6). A higher rate of absorption would result in rapid perfusion of the liver, and a potent ketogenic response.


Perhaps an important consideration: 

If you are thinking of taking this as a brain cancer patient however, it may be worth some exploration to see if your tumour has increased activity of ketolytic enzymes to see if it can use fats to proliferate. You can ask about this from histological findings. 

Ketone body ketolytic enzymes to assess expression of include (4): 

Succinyl CoA: 3 Oxoacid CoA Transferase (OXCT1)
3-hydroxybutyrate dehydrogenase 1 and 2 (BDH1 and BDH2) 
Acetyl-CoA acetyltransferase 1 (ACAT1) 


This can be the case in more aggressive tumours rather than typically lower grade, more solid tumours. I suspect this may be because the tumour is more diffuse, and as such the cell membrane may lack integrity and become more permeable. This is a theory I have based on research looking at alterations of membrane integrity and cellular constituents in neuroblastoma and glioma cells (8). 

I could be completely wrong with that theory, but either way there is often an overexpression of Fatty Acid Synthase (FASN) in high grade gliomas (7), a key lipogenic enzyme in glioma stem cells (GSCs), as well as other important metabolic enzymes, meaning aggressive tumours will try to use whatever they can to grow and thrive and are excellent at adapting to use alternative fuels when you restrict main substrates. These tumours will use glucose, amino acids, fats and nucleic acids for energy, and while the demand will be different for each, as the tumour becomes more aggressive the amounts will change and it becomes more and more resistant to even the most aggressive treatments. 







6. Odle, J., 1997. New insights into the utilization of medium-chain triglycerides by the neonate: observations from a piglet model. The Journal of nutrition127(6), pp.1061-1067.



48 comments:

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  2. Hi Andrew,
    I love your blog! Your determination and persistence to find all the best information is commendable! Just a quick question, I have had surgery for a grade 2 astrocytoma and am facing chemo/radiation. I also have multiple sclerosis. I have been able to maintain a strict keto diet and am considering supplementing with LCarnitine. What dose do you take or suggest I start with for maximum benefit?

    ReplyDelete
    Replies
    1. thank you. Personally I wouldn't have chemotherapy or radiotherapy for a grade 2 astrocytoma, its controversial even for a grade 3 so I'm not sure why your oncologist is keen to do this. Please seek 2nd and 3rd opinions on this before you make any decisions because its a huge thing. Its difficult to determine a therapeutic dose because this can depend on how your current diet is structured as well as your individual circumctances. However I notice that in most studies on cancer patients they will use at least 3,000mg per day of Acetyl-L-Carnitine. This form of carnitine is proposed to be better able to cross the blood brain barrier compared to L-Carnitine and Acetyl-L-Carnitine appears to be the preferred form of Carnitine for brain and nerve support.

      Delete
    2. I didn’t expect that reply! Lol! I have had a second opinion and the suggestion was to delay radiation but opt for temozolomide as a chemo therapy option. The rational for treatment (radiation and chemo) is adding years to my life...why do you suggest I not have chemo or radiation?

      Delete
    3. Sorry Andrew, I was hasty in my reply. What I meant was the rational of treatment was that it has been shown from clinical trials to delay the tumor from coming back by so many years. My oncologist said 3-4 with radiation alone, and 2-3 more with PCV cocktail after. That is, radiation alone delays the tumor coming back 3-4 years longer, than by doing nothing.

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    4. http://www.nejm.org/doi/pdf/10.1056/NEJMoa1500925

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  4. Hi Andrew,

    Thank you for your blog and all the research that you kindly share with us.

    I have a concern regarding L-Carnitine and Thyroid, since it is described in many papers as a thyroid hormone suppressant.

    Carnitine may partially block activity of thyroid hormones by inhibiting entry of these hormones into the nucleus of hepatocytes, neurons and fibroblasts. Thyroid hormones interact with lipid metabolism by increasing long chain fatty acid oxidation through activation of carnitine dependant fatty acid import into mitochondria. (Stargrove 2009).

    Benvenga et al proposed L-Carnitine to treat hyperthyroidism.

    We know that thyroid hormones exert a control on oxidative phosphorylation and ATP production. If L-Carnitine improves fatty acid oxidation and thus ATP production, how can that be positive if thyroid hormones are down regulated ?

    Recent research showed that T2 (3,5 diiodothyronine) supplementation, increased significantly complex IV activity and oxygen consumption in hypothyroid rats. Thus Thyroid hormones are also playing a big role in mitochondrial health and probably biogenesis.

    How do we reconcile that apparent paradox where L-Carninitine would be beneficial for the brain thanks to a better OXPHOS of fatty acids and its effects on thyroid hormones and the subsequent down regulation of OXPHOS ?

    Regards

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  8. Hi Andrew,

    Thanks for sharing this information! Curious if you could expand a little more on the "aggressive tumor" piece you concluded with. Are you saying that very aggressive tumors may also learn the "ketogenic approach" and may learn to use fats to keep growing? Was interested to see if you had any research that points to this (if that is what you're saying).

    Thanks for your time!

    ReplyDelete
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  10. As usual Rin is extremely uneducated and ignorant. Just bitterly lying about a low carb diet to justify her obesity and out control carb cravings. If you google rinfox24 you will see how obese she is unless she took down all her pics after the last time she was exposed. She really doesn't have a clue about nutrition.

    All grains make you fat. It doesn't matter if they're ancient or whole grains. They provoke hunger and inhibit nutrient absorption. All sugars make you fat, natural sugars too.

    A ketogenic diet for beginners is one that is low carb and high fat. You need fat to burn fat and to feel full and to absorb vital nutrients. You need it for your brain and organs to function. For healthy skin, hair and nails. Carbs you really don't need so much.

    You replace fat for carbs for your energy source. The fatter you are you eat more fat to burn it. You feel full all the time. Calories aren't equal. its the type you eat and not how many. If you eat low carb high fat you can eat way more calories than you ever though and still lose. If you eat low fat high carb however you have to starve yourself because thats a fattening diet.I would have to say a low ketogenic diet foods! It is a fast way to lose some weight! I am on it and am very pleased with the results I only wanted to lose ten pounds and I lost more in about a 21/2 week period and you can definitely tell! For low carb you start out by eating 20g of carbs a day for 2 weeks. By just doing this it will shock your body and after three days you will be in a state of contoses. The state of contoses is where your body will run off the 20g of carbs and the already exsisting fat/carbs and burn them away! After 2 weeks of 20g you should go to 30g for another 2 weeks, 40g-2 weeks,50g 2 weeks.. Then drop back down to 20. It is a quick way I lost.

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    Hello my fellow friends online I'm Diana Gilbert from USA, I want to use this medium to thank Dr Great because he brought back my Ex husband. my husband left me for his ex girlfriend he had before he married me it's a difficult situation for me I called and beg him to come back he refused he said he don't love me anymore I tried every possible way to get him back all was in vain I told my friend about it and she gave me Dr Great email and I emailed him and told him my problem and he told me what to do and I did it and he cast a love spell which brought back my husband within 24 hours. If you need help in getting back together with your Ex, email Dr Great at infinitylovespell@gmail.com or infinitylovespell@yahoo.com WhatsApp him+2348118829899 visit my blog http://dianagilbert05.over-blog.com/

    ReplyDelete
  22. I have being on blog Sites for a while now and today I felt like I should share my story because I was a victim too. I had HIV for 6 years and i never thought I would ever get a cure I had and this made it impossible for me to get married to the man I was supposed to get married to even after 2 years of relationship he broke up with me when he finds out I was HIV positive. So I got to know about Dr. Itua on Blog Site who treated someone and the person shared a story of how she got a cured and let her contact details, I contacted Dr. Itua and he actually confirmed it and I decided to give a try too and use his herbal medicine that was how my burden ended completely. My son will be 2 soon and I am grateful to God and thankful to his medicine too.Dr Itua Can As Well Cure The Following Disease… Cancer, HIV, Herpes, Hepatitis B, Liver Inflammatory,Diabetes,Fibroid, Get Your Ex Back, If you have (A just reach him on drituaherbalcenter@gmail.com Or Whatsapp Number.+2348149277967)He can also advise you on how to handle some marital's issues. He's a good man.

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  23. Hiv disease for the last 3 years and had pain hard to eat and cough are nightmares,especially the first year At this stage, the immune system is severely weakened, and the risk of contracting opportunistic infections is much greater. However, not everyone with HIV will go on to develop AIDS. The earlier you receive treatment, the better your outcome will be.I started taking ARV to avoid early death but I had faith in God that i would be healed someday.As a Hiv patent we are advise to be taking antiretroviral treatments to reduce our chance of transmitting the virus to others , few weeks ago i came on search on the internet if i could get any information on Hiv treatment with herbal medicine, on my search i saw a testimony of someone who has been healed from Hiv her name was Achima Abelard and other Herpes Virus patent Tasha Moore also giving testimony about this same man,Called Dr Itua Herbal Center.I was moved by the testimony and i contacted him by his Email.drituaherbalcenter@gmail.com We chatted and he send me a bottle of herbal medicine I drank it as he instructed me to.After drinking it he ask me to go for a test that how i ended my suffering life of Hiv patent,I'm cured and free of Arv Pills.I'm forever grateful to him Drituaherbalcenter.Here his contact Number +2348149277967...He assure me he can cure the following disease..Hiv,Cancer,Herpes Virus,Hpv,Pile,Weak Erection,Lyme Disease,Epilepsy, ,Bladder Cancer,Colorectal Cancer,Breast Cancer,Kidney Cancer,Leukemia,Lung Cancer,Non Hodgkin Lymphoma,Skin Cancer,Lupus,Uterine Cancer,Prostate Cancer, fibromyalgia ,ALS,Hepatitis,Copd,Parkinson disease.Genetic disease,Fibrodysplasia disease,Fibrodysplasia Ossificans Progressiva,Fluoroquinolone Toxicity Syndrome,Stroke,Hpv,Weak Erection,Liver/Kidney Inflammatory,Men/Woman infertility, bowel disease ,Huntington's disease ,Diabetes,Fibroid.

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  24. I am 29 years old and I was diagnosis of Breast cancer, easy well and have a similar story except my first acceptance as a Herbal medicine denials. I wasn’t into the movement Perseid and didn’t establish connections with any of them really, just had faith in believing how they work. I say this because it was during using Dr Itua herbal medicine i now then testify herbal medicine is real, Dr Itua herbal medicine cure my breast cancer I was suffering from for 2 years. Dr Itua herbal medicine is made of natural herbs which has no side effect and is easy to drink as well. Contact Dr Itua herbal Center if you are suffering from the same Breast Cancer or any kind of human Diseases including....HIV/AIDS, HERPES COLORECTAL CANCER, BLADDER CANCER, PROSTATE CANCER, KIDNEY CANCER, LUNG CANCER, SKIN CANCER, UTERINE CANCER, LEUKEMIA, VIRUS, HEPATITIS, WOMEN/MEN INFERTILITY, LOVE SPELL,LOTTERY SPELL. HIS CONTACT EMAIL/WHATSAPP: drituaherbalcenter@gmail.com/+2348149277967

    ReplyDelete
  25. News Health Pro simply as essential as weight loss program and workout, if now not extra. Negative sleep can power insulin resistance, throw your urge for food hormones out of whack and decrease your physical.

    https://newshealthpro.com

    ReplyDelete
  26. THE BEST LOVE SPELL CASTER ALL OVER THE WORLD

    Hey everyone My Name is cynthia From USA ,I’m so excited my broken Marriage has been restored & my husband is back after he left me and our 2 kids for another woman. After 8 years of marriage, me and my husband has been into one quarrel or the other until he finally left me and moved to Holland to be with another woman. i felt my life was over and my kids thought they would never see their father again. i tried to be strong just for the kids but i could not control the pains that torments my heart, my heart was filled with sorrows and pains because i was really in love with my husband. Every day and night i think of him and always wish he would come back to me, I was really upset and i needed help, so i searched for help online and I came across a website that suggested that Dr isiramen can help get ex back fast. So, I felt I should give him a try. I contacted him and he told me what to do and i did it then he did a (Love spell) for me. 28 hours later, my husband really called me and told me that he miss me and the kids so much, So Amazing!! So that was how he came back that same day,with lots of love and joy,and he apologized for his mistake,and for the pain he caused me and the kids. Then from that day,our Marriage was now stronger than how it were before,All thanks to Dr isiramen. he is so powerful and i decided to share my story on the internet that Dr isiramen real and powerful spell caster who i will always pray to live long to help his children in the time of trouble, if you are here and you need your Ex back or your husband moved to another woman, do not cry anymore, contact this powerful spell caster now. Here’s his contact: Email him at: oyimeanelisiramen@gmail.com, you can also call him or add him on:+2348117963221
    Whats-app:+2348117963221

    ReplyDelete
  27. Really Your Blog is Awesome! Thanks to Admin for Sharing Keto Diets related information. I Bookmarked and Shared your Link in Facebook. Keep sharing such good Articles. Additionally here I am Contributing few Similar Stories.

    6 Tips for Getting your Body ready to Start Ketosis
    Exogenous Ketones vs Endogenous Ketones
    6 Surprising benefits of Ketogenic eating that I’ve Personally Experienced
    The Modified Ketogenic Diet to Enhance Weight Loss

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  28. i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346



    i am ERIC BRUNT by name. Greetings to every one that is reading this testimony. I have been rejected by my wife after three(3) years of marriage just because another Man had a spell on her and she left me and the kid to suffer. one day when i was reading through the web, i saw a post on how this spell caster on this address AKHERETEMPLE@gmail.com have help a woman to get back her husband and i gave him a reply to his address and he told me that a man had a spell on my wife and he told me that he will help me and after 3 days that i will have my wife back. i believed him and today i am glad to let you all know that this spell caster have the power to bring lovers back. because i am now happy with my wife. Thanks for helping me Dr Akhere contact him on email: AKHERETEMPLE@gmail.com
    or
    call/whatsapp:+2349057261346

    ReplyDelete
  29. Herpes Finally Gone, thanks to Dr. Utu for his Herbal Treatment.
    I had a sudden onset of cold sores and a new one was appearing each day. I was on primary immunosuppressant I noticed my body just can't fight the virus on its own. After five days of treatment and no success I suspected herpes I went for test and it was confirmed. God was my strength I met a doctor for treatment. He gave me Dr Utu's contact. I contacted him immediately, This medication was far amazing that within 24-48 hrs the blisters were crusting over. The swelling and redness was decreasing as well. I was on four weeks herpes medication which I completed before going for test. I went for herpes test and then again back to my doctor who confirmed me herpes negative it was really like a dream. What a relief! Feel Free to contact Dr Utu Email:- drutuherbalcure@gmail.com OR WhatsApp :- +2347032718477

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  30. HSV1 & HSV2 Negative.
    Saying that, herpes virus is not curable is because you have not seen the right person to help you get rid of the virus. I testify because it's only someone who have experience this virus that konws what it means to be in this situation. After my marriage to Loe my hubby, i noticed one day that I had sudden Cold Sores in my genital part. I went for test and the doctor confirmed me being HSV2 positive.
    I felt my life and happiness with my hubby was finished. But to my greatest surprise my husband had contacted this virus and was later confirm HSV1 positive. I started noticing symptoms like cold sores, sore throat, fever blister, weakness of the body, runny nose, cough and finally the was a serious Outbreak. So I started looking for a remedy to our situation because the phamacytical drugs and the pains was too much for I and my hubby. I was looking for remedy online and different website when i saw a testimony about Dr. Akintunde and the herbal medicine that helped Erica to get rid of HSV2, I remembered my doctor told me the is no cure to this virus, I had to contact Dr. Akintunde on his WhatsApp number and told him about us and the virus, he promised to cure this virus with his herbal medicine. And he prepared four bottles of the herbal medicine and send to me through UPS delivery with instructions on how to take it. And only first week of my start, I noticed the outbreak and all the symptoms was off so, I told Dr. Akintunde about it and he said the medicine will eradicate the virus and boots my immune when i complete my medication. After I took the medicine I went back for retest and my doctor was surprised with my new status HSV2 negative my hubby also was cured. Thanks to Dr. Akintunde I am proud to say you safe our life and we remain greatful and we support your mission on humanity Sir, Do you experience such too?
    Tell Dr. Akin your health problem and be sure of total cure with his natural roots and herbs. Like Erica did testify to me I also testify for everyone who need help to be free from this inconveniencing virus, and any other health challenges you're having is curable believe me. All the best.
    Dr. Akintunde email and WhatsApp number below.
    Via email:-
    drakintundehomecare@gmail.com

    WhatsApp number:. +2347035245593

    ReplyDelete
  31. I felt my life and happiness with my hubby was finished. But to my greatest surprise my husband had contacted this virus and was later confirm HSV1 positive. I started noticing symptoms like cold sores, sore throat, fever blister, weakness of the body, runny nose, cough and finally the was a serious Outbreak.
    approximately inflammation

    ReplyDelete
  32. I'm 59 years old and female. I was diagnosed a couple of years ago with COPD and I was beyond scared! My lung function test indicated 49% capacity. After having had flu a year ago, the shortness of breath, coughing and chest pains continued even after being treated with antibiotics. I've been smoking two packs a day for 36 years. Being born without a sternum caused my ribs to be curled in just one inch away from my spine, resulting to underdeveloped lungs. At age 34 I had surgery and it was fixed. Unfortunately my smoking just caused more damage to my already under developed lungs. The problem was having is that I enjoy smoking and don't want to give up! Have tried twice before and nearly went crazy and don't want to go through that again. I saw the fear in my husband and children's eyes when I told them about my condition then they start to find solution on their own to help my condition.I am an 59 now who was diagnose COPD emphysema which I know was from my years of smoking. I started smoking in school when smoking was socially acceptable. I remember when smoking was permitted in hospitals. It was not known then how dangerous cigarettes were for us, and it seemed everybody smoked but i was able to get rid of my COPD lung condition through the help of total cure herbal foundation my husband bought, totalcureherbsfoundation.com has the right herbal formula to help you get rid and repair any lung conditions and cure you totally with their natural organic herbs,it class products at affordable prices. Purchase these medicines and get the generic medicines delivered in USA, UK & Australia,I wish anybody who starts smoking at a young age would realize what will eventually happen to their bodies if they continue that vile habit throughout their life.

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  33. Well, in my view acetyl l carnitine is the best antioxidants for our body. It helps us by different way. If we regular take this medicine in limited way then everyday we will get the proper energy for our body and we will be able to work perfectly again.

    ReplyDelete
  34. I'm also here to express my joy and tell the world the actual truth which is; there is herbal cure for HPV, all my career I've lived my life believing this. Since four years ago and till today I still say yes! Dr Osagie (drosagieherbelcentre627@gmail.com) or whatsapp number +2348160530032 Here is the doctor Website: https://drosagieherbalcentre627.weebly.com/ cures this virus using African traditional herbal medicines. After he cured me four years ago of HPV, ever since then I worked with him distance never a barrier, I'm a living witness to this. And I have directed both genital and HPV to him and they are permanently cured. I'm from USA and also a herbal dealer and lover. I'm also a researcher on herbs for good health. Which also include Africa traditional and Asian herbal treatment &Tea, I support Herbal treatment, cure and vaccines. My view is based on my extensive research over a very long period of time, and my theoretical conclusion is, there is cure to all natural diseases including HSV, HIV, CANCERS, DIABETES, HEPATITIS B, COPD, FIBROIDS using the right medications with the right herbalist. Are you HPV positive and permanently want get rid of this disease link @Dr_Osagie12 on Instagram for permanent herbal cure. Be bold and smart Don't be fooled by selfish people who say, cure is impossible.  

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  35. I have been suffering from Herpes for the past 3 years and 8 months, and ever since then i have been taking series of treatment but there was no improvement until i came across testimonies of Dr.kuta on how he has been curing different people from different diseases all over the world, then i contacted him as well. After our conversation he sent me the medicine which i took according to his instructions. When i was done taking the herbal medicine i went for a medical checkup and to my greatest surprise i was cured from Herpes. My heart is so filled with joy. If you are suffering from Herpes or any other disease you can contact Dr.kuta today on this Email address: drkutaherbalcenter@gmail.com or WhatsApp him on this Tell.Number +2347054547814

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  36. WHAT A GREAT MIRACLE THAT I HAVE EVER SEE IN MY LIFE. My names are Clara David I’m a citizen of USA, My younger sister was sicking of breast cancer and her name is Sandra David I and my family have taking her to all kind of hospital in USA still yet no good result. I decided to make search for cancer cure so that was how I find a lady called peter Lizzy she was testifying  to the world about the goodness of a herbal man who has the roots and herbs to cure all kind of disease and the herbal man email was there. So I decided to contact the herbal man @herbalist_sakura for my younger sister help to cure her breast cancer. I contacted him and told him my problem he told me that I should not worry that my sister cancer will be cure, he told me that there is a medicine that he is going to give me that I will cook it and give it to my sister to drink for one week, so I ask how can I receive the cure that I am in USA, he told me That I will pay for the delivery service. The courier service can transport it to me so he told me the amount I will pay, so my dad paid for the delivery fee. two days later I receive the cure from the courier service so I used it as the herbal man instructed me to, before the week complete my sister cancer was healed and it was like a dream to me not knowing that it was physical I and my family were very happy about the miracle of Doctor so my dad wanted to pay him 5 million us dollars the herbal man did not accept the offer from my dad, but I don't know why he didn't accept the offer, he only say that I should tell the world about him and his miracle he perform so am now here to tell the world about him if you or your relative is having any kind of disease that you can't get from the hospital please contact dr.sakuraspellalter@gmail.com or whats app him +2348110114739  you can follow him up on Instagram @herbalist_sakura for the cure, he will help you out with the problem. And if you need more information about the doctor you can mail me davidclara223@gmail.com 

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  37. My life is back!!! After 1 years of Broken marriage, my husband left me with two kids . I felt like my life was about to end I almost committed suicide, I was emotionally down for a very long time. Thanks to a spell caster called Dr Mark, which I met online. On one faithful day, as I was browsing through the internet,I came across a lot of testimonies about this particular spell caster. Some people testified that he brought their Ex lover back, some testified that he restores womb,cure cancer,and other sickness, some testified that he can cast a spell to stop divorce and so on. I also came across one particular testimony,it was about a woman called Alandre,she testified about how he brought back her Ex lover in less than 2 days, and at the end of her testimony she dropped Dr Mark e-mail address. blessedlovetemple@gmail.com After reading all these,I decided to give it a try. I contacted him via email and explained my problem to him. In just 48 hours, my husband came back to me. We solved our issues, and we are even happier than before. Dr Mark is really a gifted man and I will not stop publishing him because he is a wonderful man... If you have a problem and you are looking for a real and genuine spell caster to solve all your problems for you. blessedlovetemple@gmail.com anytime, he might be the answer to your problems.

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