Wednesday, 23 December 2015

Cancer cells adapting to use ketone bodies for fuel?

A response to an interesting study:


The bad news is: 

Cancer is very good at adapting in order to proliferate in challenging environments so this study throws up interesting talking points. 


The good news is: 

1. It will always be effective for all types of epilepsy. - including brain tumour related epilepsy (and related symptoms)

2. There are many different approaches within metabolic therapy that are effective. Central Nervous System cancers are unique in many ways. 

3. We are not rodents and other animals with more spontaneous tumours are continuing to display very encouraging long term results. 

4. Human cancer cells injected into mice have had to adapt to foreign conditions anyway so I would presume this may also be a factor to consider. 

5. The quality and type of ketogenic diet is vitally important and continues to be ignored in rodent studies (and the few human clinical trials out there). Quality of fats used is generally poor in these studies. Some even use vegetable fats!!


The study is very interesting and needs to be researched further but we need to further expand our horizons to get truly relevant data. 

Researchers often have a very narrow focus, these rodents typically aren't even monitored for seizure activity which is a very important consideration. 

I have been asked? Would be interesting to seperate the unique ketosis benefits from the normoglycemia?

Certainly, but we must remember that they are interrelated they and that it remains a fact that if quality fats are included we see that in and around malignant brain tissue we continue to see very low amounts of DHA (which is also cytotoxic to brain cancer cells). Ensuring that quality fats, particularly DHA (which makes up at least 20% of healthy brain tissue, still appears to make perfect sense when we devise an appropriate ketogenic diet. 

Personally I get frustrated at times with these ketogenic diet studies using poor quality ingredients. Im my humble opinion it should be no dairy, less omega 6, more omega 3- especially DHA. This is perhaps even more important than the ketones. I know individuals who have utilised a metabolic approach that is not strict keto and have achieved remission simply following these 'rules' so in a way I agree with the study that it isn't all about ketones. 

If the ketones are powerful metabolic tools long term, which I still believe they can be, we must consider this fact...

All ketones are not created equal. Lifestyle factors are also important and this plays a bigger role in humans, especially vitamin D status.

I've written this in about 2 minutes but when I have time after Christmas I will add all my research to back up the individual points made. It's a great study for discussion and I'm glad it's been brought to my attention. I like to question everything and I am continually adapting my methods to suit new research. 

I'm also really looking forward to Christmas Day so...

MERRY CHRISTMAS AND A HAPPY NEW YEAR!!!

5 comments:

  1. Thank you for this informative blog!! Thanks for keeping it up to date with lots of new information. I'm glad you have such an open mind and are not simply pushing an agenda--or selling a product!! Keep it up. Know there are people out there reading and enjoying your efforts.

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    Replies
    1. Thank you for taking the time to read and comment. I'm excited about learning more through my practical experiences as I start hyberbaric oxygen therapy.

      Open minds and open discussion are powerful tools for progression, especially if we do this with humility. I have learned a lot and I question a lot but I have much more to learn.

      Thank you for your support and have a lovely Christmas and New Year.

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  2. Hi Andrew, your story is amazing. I have just watched a video by Ivor Cummins and you and was blown away. What you have achieved is revolutionary. Well done. So I had to come visit your blog and had a chuckle because the "look"of your blog is exactly like mine!

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    Replies
    1. Really? Ha, thanks! It's a strong look. Great minds eh? ;)

      I'll have a read of your blog, thanks for the comment. I have a lot more work to do but it'll be a lot more fun than through the more difficult times.

      Delete
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