Monday, 2 May 2016

Clock genes, chronotherapy, exogenous ketones, MRI scans

I filmed this last week, taking some time out of my pharmacology revision to talk about chronotherapy. I still have a lot to learn but I'm really trying to get to grips with this approach in order to apply all of the theories appropriately.


I described some of the adaptations I have made over the last couple of weeks to an important aspect of my metabolic approach, using myself as a reluctant human guinea pig as always. I will do anything to achieve the best result possible, however that represents itself.


If all this sounds confusing I would thoroughly suggest giving this consice article a good read!

https://www.roswellpark.org/cancertalk/201509/coordinating-cancer-treatment-your-inner-clock

Clock genes in the brain can be powerful therapeutic tools we can exploit with chronotherapy.
IMG- http://lightawake.com/understanding_blue.php

Some methods described:

The main thing I do is to supplement with exogenous ketones through habitual junctures consistent with theories I have predicted would present a chronotherapeutic benefit- ordinarily this is when the stress hormone cortisol rises to wake me up in the morning and then subsequently adrenaline rises (between 10am and 2pm for me as an individual- this is variable of course, biochemical individuality). Fig 1 provides an example we could use to display this idea for my type of epilepsy, 'reflex epilepsy'. Fig 2 displays hormonal fluctuations in a typical sleep-wake cycle with natural light cycles.

Fig 1: IMG- http://brain.oxfordjournals.org/content/early/2016/03/31/brain.aww071.figures-only


IMG- http://hompes-method.com/testing-toolkit/adrenal-stress-hormone-testing-cortisol-and-dhea/



I also use exogenous ketones with food when I am re-feeding after a therapeutic fast to mitigate the upsurge of growth factors that may occur as the body begins to metabolise food once more.

I will often combine use of exogenous ketones with apple cider vinegar, high dose DHA fish oil gel tabs, and curcumin as I believe they could have a symbiotic benefit. DHA complements ketogenesis and curcumin improved uptake of DHA to the brain and vice versa. I have written about this previously, backing these statements up with the relevant research.


IMG- https://en.wikipedia.org/wiki/Suprachiasmatic_nucleus


I then described what chronotherapy is and how we may exploit the potential benefits to derive the most benefit. Carrying on, clock genes were introduced along with the role they play for cancer in general and for me specifically- The master circadian oscillator (the suprachiasmatic nuclei-SCN) of the hypothalamus.





IMG- https://en.wikipedia.org/wiki/Astrocyte


I explained how this relates to me specifically-

Astrocytes exert several immune functions in the central nervous system (CNS), and there is growing evidence that points toward a role of these cells in the regulation of circadian rythms.








2 comments:

  1. What an in-depth article on Chronotherapy. I’m glad to see your insight on the matter and all of the specifics in medical terms. In addition, I really liked how you related it to yourself, how the Astrocytes exert several immune functions. That made it a lot more understandable, great job in all! Now I'm ready to watch the video!

    Kacey @ Glendale MRI

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