Sunday, 8 October 2017

Evidence for use of Stiripentol and other agents to effectively inhibit cancer stem-like cell activity.

A few months ago (in March, in a previous post in my blog), I theorised that stiripentol (the 'ketogenic diet pill') may be of use as an anti-cancer agent for brain cancer and perhaps others due to inhibition of Lactate Dehydrogenase activity. I think I have just found recent evidence that this theory may be valid.
Stiripentol

Stiripentol by Diatomit enhances beneficial effects of therapeutic ketosis for cancer management by inhibiting lactate dehydrogenase and offers neuroprotection and increased seizure threshold by enhancing central GABA neurotransmission.
Here is an extra from the paper with reference to stiripentol and complimentary agents that could possibly offer a safe, synergistic therapeutic benefit.
'We have now identified a variety of clinically-approved drugs (stiripentol), natural products (caffein acid phenyl ester (CAPE), ascorbic acid, silibinin) and experimental pharmaceuticals (actinonin, FK866, 2-DG), that can be used to effectively inhibit cancer stem-like cell activity.'
The study can be found here:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5400535/

2 comments:

  1. Hi Andrew, delighted to have found your site via Andy Duff and look forward to following your adventures...my husband has been following a ketogenic diet after DX of glioblastoma. Feeling very well (though we don't currently know what 'the carbuncle' is doing as he was basically sent home to die with some steroids to control inflammation. Fascinated to read all your work. Best, Kate Everett

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  2. Hi Andrew. How did you get over your problem with salicylates? Thanks. Kate

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